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Iron-laden blasts in refractory acute myeloid leukemia.
Vossen, Christopher; Im, Roeun; Horna, Pedro.
Affiliation
  • Vossen C; Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, 200 1st St SW, MN, 55905, Rochester, USA. vossen.christopher@mayo.edu.
  • Im R; Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, 200 1st St SW, MN, 55905, Rochester, USA.
  • Horna P; Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, 200 1st St SW, MN, 55905, Rochester, USA.
J Hematop ; 16(3): 187-188, 2023 Sep.
Article in En | MEDLINE | ID: mdl-38175403
ABSTRACT
We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls' Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.
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Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Iron Limits: Humans Language: En Journal: J Hematop Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Iron Limits: Humans Language: En Journal: J Hematop Year: 2023 Type: Article Affiliation country: United States