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Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells - Implications for systemic control.
Wang, H; Mendez, L; Morton, G; Loblaw, A; Chung, H T; Cheung, P; Mesci, A; Escueta, V; Petchiny, T N; Huang, X; White, S D; Downes, M; Vesprini, D; Liu, S K.
Affiliation
  • Wang H; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada.
  • Mendez L; Division of Radiation Oncology, London Regional Cancer Program, London, ON, Canada.
  • Morton G; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Loblaw A; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada.
  • Chung HT; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Cheung P; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Mesci A; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Escueta V; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Petchiny TN; Sunnybrook Research Institute, Toronto, ON, Canada.
  • Huang X; Sunnybrook Research Institute, Toronto, ON, Canada.
  • White SD; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada.
  • Downes M; Division of Anatomic Pathology, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Vesprini D; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
  • Liu SK; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Sunnybrook Research Institute, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic add
Radiother Oncol ; 191: 110077, 2024 02.
Article in En | MEDLINE | ID: mdl-38176656
ABSTRACT
This exploratory study is a follow up to our previous investigation of immune response in the circulation of high-grade Gleason 9 prostate cancer patients treated with EBRT + BT compared to EBRT alone. Notably, EBRT + BT demonstrates the potential to elicit an effect on CD4/CD8 ratio which may have attributed to improved clinical response to therapy. Our findings show promise for leveraging circulating immune cells as predictive biomarkers for radiotherapy response.
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Brachytherapy Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Radiother Oncol Year: 2024 Type: Article Affiliation country: Canada
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Brachytherapy Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Radiother Oncol Year: 2024 Type: Article Affiliation country: Canada