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The potentiation activity of ß-lactam by phomoidrides and oxasetin against methicillin-resistant Staphylococcus aureus.
Honsho, Masako; Kimishima, Aoi; Ikeda, Akari; Iwatsuki, Masato; Nonaka, Kenichi; Matsui, Hidehito; Hanaki, Hideaki; Asami, Yukihiro; Sunazuka, Toshiaki.
Affiliation
  • Honsho M; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Kimishima A; Omura Satoshi Memorial Institute, Kitasato University, Tokyo, 108-8641, Japan.
  • Ikeda A; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Iwatsuki M; Omura Satoshi Memorial Institute, Kitasato University, Tokyo, 108-8641, Japan.
  • Nonaka K; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Matsui H; Omura Satoshi Memorial Institute, Kitasato University, Tokyo, 108-8641, Japan.
  • Hanaki H; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Asami Y; Omura Satoshi Memorial Institute, Kitasato University, Tokyo, 108-8641, Japan.
  • Sunazuka T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
J Antibiot (Tokyo) ; 77(3): 185-188, 2024 03.
Article in En | MEDLINE | ID: mdl-38177698
ABSTRACT
Antimicrobial resistance (AMR) causes a global health threat and enormous damage for humans. Among them, Methicillin-resistant Staphylococcus aureus (MRSA) resistant to first-line therapeutic ß-lactam drugs such as meropenem (MEPM) is problematic. Therefore, we focus on combination drug therapy and have been seeking new potentiators of MEPM to combat MRSA. In this paper, we report the isolation of phomoidrides A-D and its new analog, phomoidride H along with a polyketide compound, oxasetin from the culture broth of Neovaginatispora clematidis FKI-8547 strain as potentiators of MEPM against MRSA.
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Full text: 1 Database: MEDLINE Main subject: Pyrroles / Methicillin-Resistant Staphylococcus aureus Limits: Humans Language: En Journal: J Antibiot (Tokyo) Year: 2024 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Main subject: Pyrroles / Methicillin-Resistant Staphylococcus aureus Limits: Humans Language: En Journal: J Antibiot (Tokyo) Year: 2024 Type: Article Affiliation country: Japan