[Periodic dynamic observation and analysis of cellular and humoral immunity indexes of adults infected with Omicron BA.1].
Zhonghua Yu Fang Yi Xue Za Zhi
; 57(12): 2117-2121, 2023 Dec 06.
Article
in Zh
| MEDLINE
| ID: mdl-38186164
ABSTRACT
Objective:
To analyze the immunological characteristics and antibody changes of patients infected with the Omicron BA.1 and evaluate the possibility of secondary infection.Methods:
A total of 104 patients infected with Omicron BA.1 in the Jinnan District of Tianjin from January 8 to February 2, 2022, were included in the study. The control group and case group were matched 1â¶1 based on age, sex and vaccination status. Serum was collected from the case group and control group at 3, 6 and 9 months after infection. The serum levels of interleukin4 (IL-4), IL-5 and interferon-gamma (IFN-γ), as well as the positive rates of IgG, IgG1 and IgG2, were detected by ELISA.Results:
The highest concentration of IFN-γ in the case group at 6 months after infection was 145.4 pg/ml, followed by a decrease in concentration. The concentrations of IL-4 and IL-5 began to decrease at 6 months after infection (all P<0.001). There was no significant difference in the IgG2 positive rate between the case group and the control group at 6 months after BA.1 infection. However, at 9 months, there was a significant decrease compared to the control group (P=0.003). The ratio of IFN-γ/IL4 at 3 months after infection in the case group was lower than that in the control group (P<0.001). There was no significant difference in the ratio between the case group and the control group at 9 months after infection.Conclusion:
The cellular immune function has been impaired at 3 months after infection with BA.1, and the specific cellular immune and humoral immune functions decrease significantly after 6 months, and the risk of secondary infection increases.
Full text:
1
Database:
MEDLINE
Main subject:
Immunity, Humoral
/
Coinfection
Limits:
Adult
/
Humans
Language:
Zh
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2023
Type:
Article
Affiliation country:
China