The role of ncRNA regulatory mechanisms in diseases-case on gestational diabetes.
Brief Bioinform
; 25(1)2023 11 22.
Article
in En
| MEDLINE
| ID: mdl-38189542
ABSTRACT
Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not have the potential to encode proteins. Meanwhile, they can occupy a significant portion of the human genome and participate in gene expression regulation through various mechanisms. Gestational diabetes mellitus (GDM) is a pathologic condition of carbohydrate intolerance that begins or is first detected during pregnancy, making it one of the most common pregnancy complications. Although the exact pathogenesis of GDM remains unclear, several recent studies have shown that ncRNAs play a crucial regulatory role in GDM. Herein, we present a comprehensive review on the multiple mechanisms of ncRNAs in GDM along with their potential role as biomarkers. In addition, we investigate the contribution of deep learning-based models in discovering disease-specific ncRNA biomarkers and elucidate the underlying mechanisms of ncRNA. This might assist community-wide efforts to obtain insights into the regulatory mechanisms of ncRNAs in disease and guide a novel approach for early diagnosis and treatment of disease.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Carbohydrate Metabolism, Inborn Errors
/
Diabetes, Gestational
/
Malabsorption Syndromes
Type of study:
Screening_studies
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Brief Bioinform
Journal subject:
BIOLOGIA
/
INFORMATICA MEDICA
Year:
2023
Type:
Article
Affiliation country:
China