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Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.
Zhang, Xing; Ding, Xiaofeng; Wang, Chunqing; Le, Que; Wu, Dandan; Song, Anying; Huang, Guixiang; Luo, Liping; Luo, Yan; Yang, Xin; Goins, Aleyah E; Desai, Sharina P; Qiu, Chengrui; Silva, Floyd D; Feldman, Lily Elizabeth; Zhou, Jianlin; Spafford, Michael F; Boyd, Nathan H; Prossnitz, Eric R; Yang, Xuexian O; Wang, Qiong A; Liu, Meilian.
Affiliation
  • Zhang X; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Ding X; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Wang C; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Le Q; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Wu D; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Song A; Department of Molecular & Cellular Endocrinology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
  • Huang G; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China.
  • Luo L; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Luo Y; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Yang X; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Goins AE; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Desai SP; Autophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Qiu C; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Silva FD; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Feldman LE; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Zhou J; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China.
  • Spafford MF; Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Boyd NH; Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Prossnitz ER; Autophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Yang XO; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Wang QA; UNM Comprehensive Cancer Center (UNMCCC), University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Liu M; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Nat Metab ; 6(1): 78-93, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38191667
ABSTRACT
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. Here we show that in male mice, a population of transcription factor jun-B (JunB)-enriched (JunB+) adipocytes within the brown adipose tissue exhibits lower thermogenic capacity compared to high-thermogenic adipocytes. The JunB+ adipocyte population expands in obesity. Depletion of JunB in adipocytes increases the fraction of adipocytes exhibiting high thermogenic capacity, leading to enhanced basal and cold-induced energy expenditure and protection against diet-induced obesity and insulin resistance. Mechanistically, JunB antagonizes the stimulatory effects of PPARγ coactivator-1α on high-thermogenic adipocyte formation by directly binding to the promoter of oestrogen-related receptor alpha, a PPARγ coactivator-1α downstream effector. Taken together, our study uncovers that JunB shapes thermogenic adipocyte heterogeneity, serving a critical role in maintaining systemic metabolic health.
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Full text: 1 Database: MEDLINE Main subject: Insulin Resistance Type of study: Etiology_studies Limits: Animals Language: En Journal: Nat Metab Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Insulin Resistance Type of study: Etiology_studies Limits: Animals Language: En Journal: Nat Metab Year: 2024 Type: Article Affiliation country: United States