Exploring the effect of butyric acid, a metabolite from periodontopathic bacteria, on primary human melanocytes: An in vitro study.
J Oral Biosci
; 66(1): 253-259, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38215819
ABSTRACT
Effects of butyric acid, a bacterial metabolite implicated in periodontitis progression, have never been examined on oral melanocytes. Herein, primary human epidermal melanocytes were used as a model for oral melanocytes. Results show the adverse effects of butyric acid (sodium butyrate; NaB) on them, which comprise marked cytotoxicity at higher concentrations (>1 mM) and robust differentiation at lower nontoxic concentrations. NaB did not alter MITF protein levels; however, it stimulated tyrosinase protein synthesis and inhibited tyrosinase activity, with no changes in cellular melanin. NaB did not affect oxidative stress, although it induced significant levels of the pro-inflammatory cytokine IL-6.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Monophenol Monooxygenase
/
Melanocytes
Limits:
Humans
Language:
En
Journal:
J Oral Biosci
Year:
2024
Type:
Article