Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection.
Virol Sin
; 39(2): 251-263, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38219860
ABSTRACT
Viral encephalitis continues to be a significant public health concern. In our previous study, we discovered a lower expression of antiviral factors, such as IFN-ß, STING and IFI16, in the brain tissues of patients with Rasmussen's encephalitis (RE), a rare chronic neurological disorder often occurred in children, characterized by unihemispheric brain atrophy. Furthermore, a higher cumulative viral score of human herpes viruses (HHVs) was also found to have a significant positive correlation with the unihemispheric atrophy in RE. Type I IFNs (IFN-I) signaling is essential for innate anti-infection response by binding to IFN-α/ß receptor (IFNAR). In this study, we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1 (HSV-1) via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain lesions. While all mice exhibited typical viral encephalitis lesions in their brains, HSV-induced epilepsy was only observed in A6 mice. The gene expression matrix, functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced epilepsy. Additionally, ten key genes with the highest scores were identified. Taken together, these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions, thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Signal Transduction
/
Interferon Type I
/
Herpesvirus 1, Human
/
Epilepsy
/
Herpes Simplex
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Virol Sin
Journal subject:
VIROLOGIA
Year:
2024
Type:
Article
Affiliation country:
China