Herpes Zoster and Risk of Incident Parkinson's Disease in US Veterans: A Matched Cohort Study.
Mov Disord
; 39(2): 438-444, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38226430
ABSTRACT
BACKGROUND:
Although some systemic infections are associated with Parkinson's disease (PD), the relationship between herpes zoster (HZ) and PD is unclear.OBJECTIVE:
The objective is to investigate whether HZ is associated with incident PD risk in a matched cohort study using data from the US Department of Veterans Affairs.METHODS:
We compared the risk of PD between individuals with incident HZ matched to up to five individuals without a history of HZ using Cox proportional hazards regression. In sensitivity analyses, we excluded early outcomes.RESULTS:
Among 198,099 individuals with HZ and 976,660 matched individuals without HZ (median age 67.0 years (interquartile range [IQR 61.4-75.7]); 94% male; median follow-up 4.2 years [IQR 1.9-6.6]), HZ was not associated with an increased risk of incident PD overall (adjusted HR 0.95, 95% CI 0.90-1.01) or in any sensitivity analyses.CONCLUSION:
We found no evidence that HZ was associated with increased risk of incident PD in this cohort. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Veterans
/
Herpes Zoster
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Mov Disord
Journal subject:
NEUROLOGIA
Year:
2024
Type:
Article
Affiliation country:
United kingdom