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Synthesis of 2-(pyridylvinyl)chromen-4-ones and their N-oxide analogs for assessment of their biological activities as anticancer agents.
Ding, Yu Chun; Chu, Yi-Cheng; Chang, Chuan-Hsin; Liang, Jia-Hua; Chen, Jih-Jung; Shih, Tzenge-Lien.
Affiliation
  • Ding YC; Department of Chemistry, Tamkang University, New Taipei City, Taiwan.
  • Chu YC; Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Chang CH; Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Liang JH; Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • Chen JJ; Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Shih TL; Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Arch Pharm (Weinheim) ; 357(4): e2300445, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38227420
ABSTRACT
2-Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2-styrylchromones with a nitrogen atom in the benzene rings forms 2-(pyridylvinyl)chromen-4-ones (aza-2-styrylchromones). We have synthesized a series of novel 2-(pyridylvinyl)chromen-4-ones and their pyridine N-oxides to evaluate them as potential anticancer agents against human non-small-cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5-fluorouracil and showed no toxicity against normal cells.
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2024 Type: Article Affiliation country: Taiwan
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2024 Type: Article Affiliation country: Taiwan