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High Plasma Osteopontin Levels Are Associated with Serious Post-Acute-COVID-19-Related Dyspnea.
Pappas, Apostolos G; Eleftheriou, Konstantinos; Vlahakos, Vassilios; Magkouta, Sophia F; Riba, Theofani; Dede, Konstantina; Siampani, Rafaela; Kompogiorgas, Steven; Polydora, Eftychia; Papalampidou, Athanasia; Loutsidi, Natasa-Eleni; Mantas, Nikolaos; Tavernaraki, Ekaterini; Exarchos, Demetrios; Kalomenidis, Ioannis.
Affiliation
  • Pappas AG; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Eleftheriou K; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Vlahakos V; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Magkouta SF; "Marianthi Simou Laboratory", First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Riba T; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Dede K; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Siampani R; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Kompogiorgas S; Department of Pulmonary Medicine, "Evangelismos" General Hospital, 10676 Athens, Greece.
  • Polydora E; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Papalampidou A; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
  • Loutsidi NE; Hematology-Lymphomas Department and Bone Marrow Transplant Unit, "Evangelismos" General Hospital, 10676 Athens, Greece.
  • Mantas N; Department of CT-MRI, "Evangelismos" General Hospital, 10676 Athens, Greece.
  • Tavernaraki E; Department of CT-MRI, "Evangelismos" General Hospital, 10676 Athens, Greece.
  • Exarchos D; Department of CT-MRI, "Evangelismos" General Hospital, 10676 Athens, Greece.
  • Kalomenidis I; First Department of Critical Care and Pulmonary Medicine, "Evangelismos" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
J Clin Med ; 13(2)2024 Jan 10.
Article in En | MEDLINE | ID: mdl-38256526
ABSTRACT
COVID-19 survivors commonly report persistent symptoms. In this observational study, we investigated the link between osteopontin (OPN) and post-acute COVID-19 symptoms and lung functional/imaging abnormalities. We recorded symptoms and lung imaging/functional data from previously hospitalized COVID-19 patients, who were followed for 4-84 weeks (122 patients/181 visits) post-symptom onset at our outpatient clinic. Circulating OPN was determined using ELISA. Plasma OPN levels were higher in symptomatic patients (compared with the asymptomatic ones); those with dyspnea (compared with those without dyspnea);those with a combination of serious symptoms, i.e., the presence of at least one of the following dyspnea, fatigue and muscular weakness (compared with those with none of these symptoms); and those with dyspnea and m-MRC > 1 (compared with those with m-MRC = 0-1). Plasma OPN levels were inversely correlated with EQ-VAS (visual analog scale of the EQ-5D-5L health-related quality-of-life questionnaire) values. High-resolution CT or diffusion lung capacity (DLCO) findings were not related to circulating OPN. In the multiple logistic regression, the presence of symptoms, dyspnea, or the combination of serious symptoms were linked to female gender, increased BMI and pre-existing dyspnea (before the acute disease), while increased plasma OPN levels, female gender and pre-existing dyspnea with m-MRC > 1 were independently associated with severe post-COVID-19 dyspnea (m-MRC > 1). Using a correlation matrix to investigate multiple correlations between EQ-VAS, OPN and epidemiological data, we observed an inverse correlation between the OPN and EQ-VAS values. Increased circulating OPN was linked to the persistence of severe exertional dyspnea and impaired quality of life in previously hospitalized COVID-19 patients.
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Full text: 1 Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: J Clin Med Year: 2024 Type: Article Affiliation country: Greece

Full text: 1 Database: MEDLINE Type of study: Observational_studies / Risk_factors_studies Language: En Journal: J Clin Med Year: 2024 Type: Article Affiliation country: Greece