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An unusual form of BRAF-V600E mutated hairy cell neoplasm with clinical resistance to BRAF inhibition: Challenging precision medicine.
Marra, Andrea; Santi, Alessia; Pucciarini, Alessandra; Venanzi, Alessandra; De Carolis, Luca; Zaja, Francesco; Ascani, Stefano; Canzonieri, Vincenzo; Ballanti, Stelvio; Falini, Brunangelo; Tiacci, Enrico.
Affiliation
  • Marra A; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
  • Santi A; Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Pucciarini A; Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome, Italy.
  • Venanzi A; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
  • De Carolis L; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
  • Zaja F; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
  • Ascani S; Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
  • Canzonieri V; Hematology Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
  • Ballanti S; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Falini B; Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, Terni, Italy.
  • Tiacci E; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Am J Hematol ; 99(3): 497-501, 2024 03.
Article in En | MEDLINE | ID: mdl-38264797
ABSTRACT
Distinct outcomes of BRAF inhibition in BRAF-mutated hairy cell neoplasms with wild-type or mutant TP53, and alternative strategies to overcome mutant TP53.
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins B-raf / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Am J Hematol Year: 2024 Type: Article Affiliation country: Italy
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins B-raf / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Am J Hematol Year: 2024 Type: Article Affiliation country: Italy