Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster.
Methods Mol Biol
; 2753: 317-330, 2024.
Article
in En
| MEDLINE
| ID: mdl-38285347
ABSTRACT
Drosophila melanogaster is one of the crucial in vivo models in terms of analyzing the toxicity of various unknown chemicals. Every part of the fly serves as a model in metabolic and therapeutic approaches. Genotoxic and teratogenic compounds are exposed to Drosophila through the oral route. Further, the toxicity of genotoxic compounds is analyzed in Drosophila's gut, hemolymph, and phenotype. The toxicity of teratogen compounds is also analyzed using a Drosophila embryo. The current chapter summarizes several techniques that are used to detect the genotoxicity and teratogenicity of any unknown compound in this model.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Teratogens
/
Teratogenesis
Limits:
Animals
Language:
En
Journal:
Methods Mol Biol
/
Methods in molecular biology
/
Methods mol. biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Type:
Article
Affiliation country:
India