Cresyl Diphenyl Phosphate exposure induces reproductive functional defects in men and male mice.
Ecotoxicol Environ Saf
; 271: 116003, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38286103
ABSTRACT
Cresyl Diphenyl Phosphate (CDP), as a novel organophosphate esters (OPEs), achieves widely used and exposed in multiple industries. However, its male reproductive toxicity and underlying mechanism remains unclear. In vivo, male mice were gavaged with CDP (0, 4, 20, or 100 mg/kg/d) for 8 weeks. And we treated TM3, TM4 and GC-2 cells with 0, 10, 25, and 50 µM CDP for 24 h to detect its reproductive toxicity effect in vitro. In our study, we revealed that CDP inhibited proliferation and induced apoptosis in mice testis and GC-2 cells, thereby leading to the decreased sperm quality. In mechanism, CDP trigger the oxidative stress and ROS production, thus partially causing DNA damage and cell apoptosis. Moreover, CDP exposure causes injury to Ledyig cells and Sertoli cells, thus disturbing the testicular microenvironment and inhibiting spermatogonia proliferation. In conclusion, this research reveals multiple adverse impacts of CDP on the male reproductive system and calls for further study of the toxicological effects of CDP on human health.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Semen
/
Testis
/
Biphenyl Compounds
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Ecotoxicol Environ Saf
Year:
2024
Type:
Article
Affiliation country:
China