Structure is beauty, but not always truth.
Cell
; 187(3): 517-520, 2024 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-38306978
ABSTRACT
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets." Overcoming these challenges will amplify the impact of structural biology on drug discovery.
Full text:
1
Database:
MEDLINE
Main subject:
Drug Discovery
/
Molecular Biology
Language:
En
Journal:
Cell
Year:
2024
Type:
Article