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Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan.
Lluís, Núria; Onoe, Shunsuke; Serradilla-Martín, Mario; Achalandabaso, Mar; Mizuno, Takashi; Jehaes, François; Dasari, Bobby V M; Mambrilla-Herrero, Sara; Sparrelid, Ernesto; Balakrishnan, Anita; Hoogwater, Frederik J H; Amaral, María J; Andersson, Bodil; Berrevoet, Frederik; Doussot, Alexandre; López-López, Víctor; Detry, Olivier; Pozo, Carlos Domingo-Del; Machairas, Nikolaos; Pekli, Damján; Alcázar-López, Cándido F; Asbun, Horacio; Björnsson, Bergthor; Christophides, Thalis; Díez-Caballero, Alberto; Francart, David; Noel, Colin B; Sousa-Silva, Donzília; Toledo-Martínez, Enrique; Tzimas, George N; Yaqub, Sheraz; Yamaguchi, Junpei; Dokmak, Safi; Prieto-Calvo, Mikel; D'Souza, Melroy A; Spiers, Harry V M; van den Heuvel, Marius C; Charco, Ramón; Lesurtel, Mickaël; Ebata, Tomoki; Ramia, José M.
Affiliation
  • Lluís N; Division of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL, USA. Electronic address: nurialluisv@gmail.com.
  • Onoe S; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Serradilla-Martín M; Instituto de Investigación Sanitaria Aragón, Department of Surgery, Miguel Servet University Hospital, Zaragoza, Spain. Electronic address: marioserradilla@hotmail.com.
  • Achalandabaso M; HPB Surgery and Transplantation, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
  • Mizuno T; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Jehaes F; HPB Surgery & Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, France.
  • Dasari BVM; Liver Transplant and HPB Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom.
  • Mambrilla-Herrero S; Hepatobiliary Surgery and Liver Transplant Unit, Cruces University Hospital, Bilbao, Spain.
  • Sparrelid E; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Balakrishnan A; Cambridge HPB Unit, Cambridge University Hospitals NHS Foundation Trust, and Department of Surgery, University of Cambridge, Cambridge, UK.
  • Hoogwater FJH; HPB Surgery and Liver Transplantation, and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Amaral MJ; General Surgery, Centro Hospitalar e Universitário de Coimbra, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Andersson B; Department of Clinical Science Lund, Surgery, Lund University and Skane University Hospital, Lund, Sweden.
  • Berrevoet F; General and HPB Surgery, and Liver Transplantation, University Hospital Gent, Gent, Belgium.
  • Doussot A; Department of Digestive Surgical Oncology, Liver Transplantation Unit, CHU Besançon, France.
  • López-López V; General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, Spain.
  • Detry O; Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Belgium.
  • Pozo CD; General and Digestive Surgery, Hospital Doctor Peset, Valencia, Spain.
  • Machairas N; Second Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Athens, Greece.
  • Pekli D; Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary.
  • Alcázar-López CF; HPB Surgery and Liver Transplantation, Dr. Balmis General University Hospital, and Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
  • Asbun H; Division of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL, USA.
  • Björnsson B; Department of Surgery in Linköping and Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Christophides T; General Surgery Department, HPB Division, Nicosia General Hospital, Nicosia, Cyprus.
  • Díez-Caballero A; Quirúrgica Cirujanos Asociados, Centro Médico Teknon, Barcelona, Spain.
  • Francart D; Department of Abdominal Surgery, CHC Groupe Santé, Liège, Belgium.
  • Noel CB; HPB Clinical Unit, Gastrointestinal Surgery, Universitas Academic Hospital, University of the Free State, South Africa.
  • Sousa-Silva D; HEBIPA Surgery, Centro Hospitalar Universitário do Porto, Portugal.
  • Toledo-Martínez E; Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Tzimas GN; HPB Surgery, Department of Surgery, Hygeia Hospital, Athens, Greece.
  • Yaqub S; HPB Surgery, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Yamaguchi J; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Dokmak S; HPB Surgery & Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, France.
  • Prieto-Calvo M; Hepatobiliary Surgery and Liver Transplant Unit, Cruces University Hospital, Bilbao, Spain.
  • D'Souza MA; Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Spiers HVM; Cambridge HPB Unit, Cambridge University Hospitals NHS Foundation Trust, and Department of Surgery, University of Cambridge, Cambridge, UK.
  • van den Heuvel MC; HPB Surgery and Liver Transplantation, and Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Charco R; HPB Surgery and Transplantation, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
  • Lesurtel M; HPB Surgery & Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, France.
  • Ebata T; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ramia JM; HPB Surgery and Liver Transplantation, Dr. Balmis General University Hospital, and Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain; Miguel Hernández University, Alicante, Spain.
HPB (Oxford) ; 26(4): 565-575, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38307773
ABSTRACT

BACKGROUND:

Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB.

METHODS:

A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan.

RESULTS:

A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P < .001), less invasive carcinoma (42% vs 85%, P < .001), and more intrahepatic tumors (52% vs 24%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33% vs 68%, P < .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions.

DISCUSSION:

Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.
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Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Bile Ducts, Intrahepatic Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: HPB (Oxford) Journal subject: GASTROENTEROLOGIA Year: 2024 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Bile Duct Neoplasms / Bile Ducts, Intrahepatic Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: HPB (Oxford) Journal subject: GASTROENTEROLOGIA Year: 2024 Type: Article