Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis.
Annu Rev Biomed Eng
; 26(1): 119-139, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38316063
ABSTRACT
Recent advances in single-cell and multicellular microfluidics technology have provided powerful tools for studying cancer biology and immunology. The ability to create controlled microenvironments, perform high-throughput screenings, and monitor cellular interactions at the single-cell level has significantly advanced our understanding of tumor biology and immune responses. We discuss cutting-edge multicellular and single-cell microfluidic technologies and methodologies utilized to investigate cancer-immune cell interactions and assess the effectiveness of immunotherapies. We explore the advantages and limitations of the wide range of 3D spheroid and single-cell microfluidic models recently developed, highlighting the various approaches in device generation and applications in immunotherapy screening for potential opportunities for point-of-care approaches.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Point-of-Care Systems
/
Microfluidics
/
Single-Cell Analysis
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Biomed Eng
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2024
Type:
Article