Using the 'Leapfrog' Design as a Simple Form of Adaptive Platform Trial to Develop, Test, and Implement Treatment Personalization Methods in Routine Practice.
Adm Policy Ment Health
; 2024 Feb 05.
Article
in En
| MEDLINE
| ID: mdl-38316652
ABSTRACT
The route for the development, evaluation and dissemination of personalized psychological therapies is complex and challenging. In particular, the large sample sizes needed to provide adequately powered trials of newly-developed personalization approaches means that the traditional treatment development route is extremely inefficient. This paper outlines the promise of adaptive platform trials (APT) embedded within routine practice as a method to streamline development and testing of personalized psychological therapies, and close the gap to implementation in real-world settings. It focuses in particular on a recently-developed simplified APT design, the 'leapfrog' trial, illustrating via simulation how such a trial may proceed and the advantages it can bring, for example in terms of reduced sample sizes. Finally it discusses models of how such trials could be implemented in routine practice, including potential challenges and caveats, alongside a longer-term perspective on the development of personalized psychological treatments.
Full text:
1
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Adm Policy Ment Health
Journal subject:
PSICOLOGIA
/
SAUDE PUBLICA
/
SERVICOS DE SAUDE
Year:
2024
Type:
Article
Affiliation country:
Germany