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Visible Light Mediated Chemoselective Hydroxylation of Benzylic Methylenes.
Tan, Zhiyong; Chen, Tingting; Zhu, Jinbin; Luo, Wenjun; Yu, Daohong; Guo, Wei.
Affiliation
  • Tan Z; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
  • Chen T; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
  • Zhu J; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
  • Luo W; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
  • Yu D; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
  • Guo W; Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China.
J Org Chem ; 89(4): 2656-2664, 2024 Feb 16.
Article in En | MEDLINE | ID: mdl-38324782
ABSTRACT
We have developed a metal-free photocatalytic selective hydroxylation of benzylic methylenes to secondary alcohols. This approach utilizes low-cost eosin Y as photocatalyst, O2 as green oxidant, and inexpensive triethylamine as inhibitor for overoxidation. The mild reaction conditions enable the production of secondary alcohols with 56-95% yields, making it a promising and environmental-friendly method for the synthesis of secondary alcohols from benzylic methylenes.
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Full text: 1 Database: MEDLINE Language: En Journal: J Org Chem Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Language: En Journal: J Org Chem Year: 2024 Type: Article Affiliation country: China