Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca2+-Binding Motif.
Org Lett
; 26(7): 1343-1347, 2024 Feb 23.
Article
in En
| MEDLINE
| ID: mdl-38329455
ABSTRACT
Genome analysis of strain Streptomyces sp. CA-278952 revealed a biosynthetic gene cluster encoding a putative lipopeptide with a sequence containing an Asp-Gly-Glu-Ala motif. We envisioned that this motif could mimic the canonical Asp-X-Asp-Gly sequence found in previously reported calcium-dependent lipopeptide antibiotics. Chemical investigation of the producing strain led to the discovery of three novel lipodepsipeptides, dilarmycins A-C. The calcium-dependent antibacterial activity of the new compounds was confirmed against the Gram-positive pathogens methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
Full text:
1
Database:
MEDLINE
Main subject:
Methicillin-Resistant Staphylococcus aureus
/
Anti-Bacterial Agents
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2024
Type:
Article
Affiliation country:
Spain