Early and mid-term outcomes after aortic valve replacement using a novel tissue bioprosthesis: a systematic review.
Eur J Cardiothorac Surg
; 65(2)2024 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-38331412
ABSTRACT
OBJECTIVES:
While current data show a clear trend towards the use of bioprosthetic valves during aortic valve replacement (AVR), durability of bioprosthetic valves remains the most important concern. We conducted a 1st systematic review of all available evidence that analysed early and mid-term outcomes after AVR using the Inspiris RESILIA™ bioprosthesis.METHODS:
A systematic literature search was performed to identify all relevant studies evaluating early and mid-term outcomes after AVR using the Inspiris RESILIA bioprosthesis and including at least 20 patients with no restriction on the publication date. Subgroup meta-analysis was performed to compare Inspiris RESILIA and PERIMOUNT Magna Ease bioprosthesis and to pool the early postoperative mortality and stroke rates.RESULTS:
A total of 416 studies were identified, of which 15 studies met the eligibility criteria. The studies included a total of 3202 patients with an average follow-up of up to 5.3 years. The average age of patients across the studies was 52.2-75.1 years. Isolated AVR was performed in 39.0-86.4% of patients. In-hospital or 30-day postoperative mortality was 0-2.8%. At the mid-term follow-up, freedom from all-cause mortality was up to 85.4%. Among studies with mid-term follow-up, trace/mild paravalvular leak was detected in 0-3.0%, while major paravalvular leak was found only in up to 2.0% of patients. No statistically significant differences in terms of mortality (P = 0.98, odds ratio 1.02, 95% confidence interval 0.36-2.83) and stroke (P = 0.98, odds ratio 1.01, 95% confidence interval 0.38-2.73) between the Inspiris RESILIA bioprosthesis and PERIMOUNT Magna Ease bioprosthesis were observed in the subgroup meta-analysis.CONCLUSIONS:
Mid-term data on the safety and haemodynamic performance of the novel aortic bioprosthesis are encouraging. Further comparative studies with other bioprostheses and longer follow-up are still required to endorse durability and safety of the novel bioprosthesis.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Aortic Valve
/
Bioprosthesis
/
Heart Valve Prosthesis
/
Heart Valve Prosthesis Implantation
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Aged
/
Humans
Language:
En
Journal:
Eur J Cardiothorac Surg
/
Eur. j. cardiothorac. surg
/
European journal of cardio-thoracic surgery
Journal subject:
CARDIOLOGIA
Year:
2024
Type:
Article