Paeoniflorin loaded liposomes modified with glycyrrhetinic acid for liver-targeting: preparation, characterization, and pharmacokinetic study.
Pharm Dev Technol
; 29(3): 176-186, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38376879
ABSTRACT
OBJECTIVE:
To enhance the retention times and therapeutic efficacy of paeoniflorin (PF), a liver-targeted drug delivery system has been developed using glycyrrhetinic acid (GA) as a ligand.SIGNIFICANCE:
The development and optimization of GA-modified PF liposomes (GPLs) have shown promising potential for targeted delivery to the liver, opening up new possibilities for liver disease treatment.METHODS:
This study aimed to identify the best prescriptions using single-factor experiments and response surface methodology. The formulation morphology was determined using transmission electron microscopy. Tissue distribution was observed through in vivo imaging, and pharmacokinetic studies were conducted.RESULTS:
The results indicated that GPLs, prepared using the thin film dispersion method and response surface optimization, exhibited well-dispersed and uniformly sized particles. The in vitro release rate of GPLs was slower compared to PF monomers, suggesting a sustained release effect. The liver-targeting ability of GA resulted in stronger fluorescence signals in the liver for targeted liposomes compared to non-targeted liposomes. Furthermore, pharmacokinetic studies demonstrated that GPLs significantly prolonged the residence time of PF in the bloodstream, thereby contributing to prolonged efficacy.CONCLUSION:
These findings suggest that GPLs are more effective than PF monomers in terms of controlling drug release and delivering drugs to specific targets, highlighting the potential of PF as a liver-protective drug.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Monoterpenes
/
Glucosides
/
Glycyrrhetinic Acid
/
Liposomes
Language:
En
Journal:
Pharm Dev Technol
/
Pharm. dev. technol
/
Pharmaceutical development and technology
Journal subject:
FARMACIA
Year:
2024
Type:
Article
Affiliation country:
China