Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota.
Int J Food Sci Nutr
; 75(4): 369-384, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38389248
ABSTRACT
The high-fat diet would lead to excessive fat storage in the liver to form metabolic dysfunction-associated steatotic liver disease (MASLD), and the trend is burgeoning. The aim of the study is to investigate the effects of chlorogenic acid (CGA) on metabolites and gut microorganisms in MASLD mice induced by a high-fat diet. In comparison to the HF group, the TC (total cholesterol), TG (total triglycerides), LDL-C (low-density lipoprotein cholesterol), AST (aspartate aminotransferase) and ALT (alanine transaminase) levels were reduced after CGA supplement. CGA led to an increase in l-phenylalanine, l-tryptophan levels, and promoted fatty acid degradation. CGA increased the abundance of the Muribaculaceae, Bacteroides and Parabacteroides. Changes in these microbes were significantly associated with the liver metabolites level and lipid profile level. These data suggest important roles for CGA regulating the gut microbiota, liver and caecum content metabolites, and TG-, TC- and LDL-C lowering function.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Chlorogenic Acid
/
Diet, High-Fat
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Gastrointestinal Microbiome
/
Liver
/
Mice, Inbred C57BL
Limits:
Animals
Language:
En
Journal:
Int J Food Sci Nutr
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2024
Type:
Article
Affiliation country:
China