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Phage-inspired strategies to combat antibacterial resistance.
Wang, Mianzhi; Zhang, Junxuan; Wei, Jingyi; Jiang, Lei; Jiang, Li; Sun, Yongxue; Zeng, Zhenling; Wang, Zhiqiang.
Affiliation
  • Wang M; College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
  • Zhang J; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
  • Wei J; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Jiang L; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangzhou, China.
  • Jiang L; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
  • Sun Y; College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
  • Zeng Z; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
  • Wang Z; College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Crit Rev Microbiol ; 50(2): 196-211, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38400715
ABSTRACT
Antimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth, showing great attraction as potential antibacterial therapeutics in combating AMR. This review provides a summary of phage-inspired strategies to combat AMR. We firstly cover the phage diversity, and then explain the biological principles of phage therapy that support the use of phages in the post-antimicrobial era. Furthermore, we state the versatility methods of phage therapy both from direct access as well as collateral access. Among the direct access approaches, we discuss the use of phage cocktail therapy, phage-encoded endolysins and the bioengineering for function improvement of used phages or endolysins. On the other hand, we introduce the collateral access, including the phages antimicrobial immunity combined therapy and phage-based novel antibacterial mimic molecules. Nowadays, more and more talented and enthusiastic scientist, doctors, pharmacists, media, authorities, and industry are promoting the progress of phage therapy, and proposed more phages-inspired strategy to make them more tractable to combat AMR and benefit more people, more animal and diverse environment in "one health" framework.
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Full text: 1 Database: MEDLINE Main subject: Bacteriophages Limits: Animals / Humans Language: En Journal: Crit Rev Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Bacteriophages Limits: Animals / Humans Language: En Journal: Crit Rev Microbiol Journal subject: MICROBIOLOGIA Year: 2024 Type: Article Affiliation country: China