SingleQ: a comprehensive database of single-cell expression quantitative trait loci (sc-eQTLs) cross human tissues.
Database (Oxford)
; 20242024 Mar 09.
Article
in En
| MEDLINE
| ID: mdl-38459946
ABSTRACT
Mapping of expression quantitative trait loci (eQTLs) and other molecular QTLs can help characterize the modes of action of disease-associated genetic variants. However, current eQTL databases present data from bulk RNA-seq approaches, which cannot shed light on the cell type- and environment-specific regulation of disease-associated genetic variants. Here, we introduce our Single-cell eQTL Interactive Database which collects single-cell eQTL (sc-eQTL) datasets and provides online visualization of sc-eQTLs across different cell types in a user-friendly manner. Although sc-eQTL mapping is still in its early stage, our database curates the most comprehensive summary statistics of sc-eQTLs published to date. sc-eQTL studies have revolutionized our understanding of gene regulation in specific cellular contexts, and we anticipate that our database will further accelerate the research of functional genomics. Database URL http//www.sqraolab.com/scqtl.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Quantitative Trait Loci
Limits:
Humans
Language:
En
Journal:
Database (Oxford)
Year:
2024
Type:
Article