Bibenzyl-Phenylpropane Hybrids with Immunosuppressive Activities from Dendrobium Nobile Lindl.
Chem Biodivers
; 21(5): e202400283, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38485665
ABSTRACT
Fifteen bibenyls and four fluorenones, including five new bibenzyl-phenylpropane hybrids, were isolated from the aerial part of Dendrobium nobile Lindl. Their structures were determined by spectroscopic methods. Bioassay on the LPS-induced proliferations of mouse splenic B lymphocytes, and Con A-induced T lymphocytes showed that compounds 1, 2, and 14 showed excellent immunosuppressive activities with IC50 values of 1.23, 1.01, and 3.87â
µM, respectively, while compoundsâ
3-4, 7, 10, 13, and 15 exhibited moderate immunosuppressive activities with IC50 values ranging from 6.89 to 14.2â
µM.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bibenzyls
/
Dendrobium
/
Cell Proliferation
/
Immunosuppressive Agents
Limits:
Animals
Language:
En
Journal:
Chem Biodivers
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2024
Type:
Article