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Advancements in chimeric antigen receptor-expressing T-cell therapy for glioblastoma multiforme: Literature review and future directions.
Goutnik, Michael; Iakovidis, Alexandria; Still, Megan E H; Moor, Rachel S F; Melnick, Kaitlyn; Yan, Sandra; Abbas, Muhammad; Huang, Jianping; Ghiaseddin, Ashley P.
Affiliation
  • Goutnik M; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Iakovidis A; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Still MEH; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Moor RSF; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Melnick K; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Yan S; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Abbas M; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Huang J; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Ghiaseddin AP; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Neurooncol Adv ; 6(1): vdae025, 2024.
Article in En | MEDLINE | ID: mdl-38486856
ABSTRACT
Glioblastoma multiforme (GBM) is an aggressive cancer that has been difficult to treat and often requires multimodal therapy consisting of surgery, radiotherapy, and chemotherapy. Chimeric antigen receptor-expressing (CAR-T) cells have been efficacious in treating hematological malignancies, resulting in several FDA-approved therapies. CAR-T cells have been more recently studied for the treatment of GBM, with some promising preclinical and clinical results. The purpose of this literature review is to highlight the commonly targeted antigens, results of clinical trials, novel modifications, and potential solutions for challenges that exist for CAR-T cells to become more widely implemented and effective in eradicating GBM.
Key words

Full text: 1 Database: MEDLINE Language: En Journal: Neurooncol Adv Year: 2024 Type: Article Affiliation country: United States

Full text: 1 Database: MEDLINE Language: En Journal: Neurooncol Adv Year: 2024 Type: Article Affiliation country: United States