Describing calcium pyrophosphate deposition: undoing the tower of Babel!
Curr Opin Rheumatol
; 36(3): 241-250, 2024 05 01.
Article
in En
| MEDLINE
| ID: mdl-38517340
ABSTRACT
PURPOSE OF REVIEW In 1977, McCarty astutely observed, 'The variety of names suggested for the condition associated with deposits of calcium pyrophosphate dihydrate crystals is exceeded only by the variations of its clinical presentation'. Fast forward to 2024, a standardized nomenclature for calcium pyrophosphate deposition (CPPD) is still lacking. This review aims to delineate the challenges in characterizing CPPD through nomenclature and imaging. RECENT FINDINGS:
Despite the effort of nomenclature standardization in 2011 by the EULAR, confusion persists in the literature and clinical practice, with pseudo-forms and obscure abbreviations. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) has launched a project to redefine CPPD nomenclature and formulate a user-friendly language for effective communication with patients and other stakeholders. Additionally, recent advancements in imaging, have shed light on various aspects of the disorder.SUMMARY:
Almost 60âyears from the first description of a clinical manifestation related to calcium pyrophosphate crystals, a common language describing the disorder is still lacking. A redefined CPPD nomenclature, together with lay-friendly terminology, would significantly contribute to the uniformity of CPPD research, enhance public understanding and awareness and improve doctor-patient communication and therefore disease outcomes. Imaging can provide deep insights into CPPD elements, promoting comprehension of this disorder.
Full text:
1
Database:
MEDLINE
Main subject:
Calcinosis
/
Chondrocalcinosis
/
Gout
Limits:
Humans
Language:
En
Journal:
Curr Opin Rheumatol
Journal subject:
REUMATOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Italy