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Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.
Fisher, Allison L; Phillips, Sydney; Wang, Chia-Yu; Paulo, Joao A; Xiao, Xia; Moschetta, Gillian A; Sridhar, Adhvaith; Mancias, Joseph D; Babitt, Jodie L.
Affiliation
  • Fisher AL; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Phillips S; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Wang CY; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA.
  • Xiao X; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Moschetta GA; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Sridhar A; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
  • Babitt JL; Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Blood ; 143(23): 2433-2437, 2024 Jun 06.
Article in En | MEDLINE | ID: mdl-38518102
ABSTRACT
ABSTRACT Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.
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Full text: 1 Database: MEDLINE Main subject: Cation Transport Proteins / Bone Morphogenetic Protein 6 / Iron Limits: Animals Language: En Journal: Blood Year: 2024 Type: Article Affiliation country: Morocco
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Full text: 1 Database: MEDLINE Main subject: Cation Transport Proteins / Bone Morphogenetic Protein 6 / Iron Limits: Animals Language: En Journal: Blood Year: 2024 Type: Article Affiliation country: Morocco