Programmable ultrasound imaging guided theranostic nanodroplet destruction for precision therapy of breast cancer.
Ultrason Sonochem
; 105: 106854, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38537562
ABSTRACT
Ultrasound-stimulated contrast agents have gained significant attention in the field of tumor treatment as drug delivery systems. However, their limited drug-loading efficiency and the issue of bulky, imprecise release have resulted in inadequate drug concentrations at targeted tissues. Herein, we developed a highly efficient approach for doxorubicin (DOX) precise release at tumor site and real-time feedback via an integrated strategy of "programmable ultrasonic imaging guided accurate nanodroplet destruction for drug release" (PND). We synthesized DOX-loaded nanodroplets (DOX-NDs) with improved loading efficiency (15 %) and smaller size (mean particle size 358 nm). These DOX-NDs exhibited lower ultrasound activation thresholds (2.46 MPa). By utilizing a single diagnostic transducer for both ultrasound stimulation and imaging guidance, we successfully vaporized the DOX-NDs and released the drug at the tumor site in 4 T1 tumor-bearing mice. Remarkably, the PND group achieved similar tumor remission effects with less than half the dose of DOX required in conventional treatment. Furthermore, the ultrasound-mediated vaporization of DOX-NDs induced tumor cell apoptosis with minimal damage to surrounding normal tissues. In summary, our PND strategy offers a precise and programmable approach for drug delivery and therapy, combining ultrasound imaging guidance. This approach shows great potential in enhancing tumor treatment efficacy while minimizing harm to healthy tissues.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Doxorubicin
/
Nanoparticles
/
Theranostic Nanomedicine
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Ultrason Sonochem
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2024
Type:
Article
Affiliation country:
China