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An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade.
Houbaert, Diede; Nikolakopoulos, Apostolos Panagiotis; Jacobs, Kathryn A; Meçe, Odeta; Roels, Jana; Shankar, Gautam; Agrawal, Madhur; More, Sanket; Ganne, Maarten; Rillaerts, Kristine; Boon, Louis; Swoboda, Magdalena; Nobis, Max; Mourao, Larissa; Bosisio, Francesca; Vandamme, Niels; Bergers, Gabriele; Scheele, Colinda L G J; Agostinis, Patrizia.
Affiliation
  • Houbaert D; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Nikolakopoulos AP; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Jacobs KA; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; Laboratory of Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Meçe O; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Roels J; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; VIB Single Cell Core, Leuven, Belgium.
  • Shankar G; Laboratory of Translational Cell and Tissue Research, Department of Pathology, KU Leuven and UZ Leuven, Leuven, Belgium.
  • Agrawal M; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • More S; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Ganne M; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Rillaerts K; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Boon L; JJP Biologics, Warsaw, Poland.
  • Swoboda M; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium.
  • Nobis M; Intravital Imaging Expertise Center, VIB-CCB, Leuven, Belgium.
  • Mourao L; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Bosisio F; Laboratory of Translational Cell and Tissue Research, Department of Pathology, KU Leuven and UZ Leuven, Leuven, Belgium.
  • Vandamme N; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; VIB Single Cell Core, Leuven, Belgium.
  • Bergers G; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; Laboratory of Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Scheele CLGJ; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium; Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Agostinis P; Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology Research (CCB), Leuven, Belgium. Electronic address: patrizia.agostinis@kuleuven.be.
Cell Rep ; 43(4): 114020, 2024 Apr 23.
Article in En | MEDLINE | ID: mdl-38554280
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Full text: 1 Database: MEDLINE Main subject: Sphingosine / Autophagy / T-Lymphocytes / Immune Checkpoint Inhibitors / Lymph Nodes Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2024 Type: Article Affiliation country: Belgium
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Full text: 1 Database: MEDLINE Main subject: Sphingosine / Autophagy / T-Lymphocytes / Immune Checkpoint Inhibitors / Lymph Nodes Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2024 Type: Article Affiliation country: Belgium