PD-L1+ macrophages suppress T cell-mediated anticancer immunity.
Oncoimmunology
; 13(1): 2338951, 2024.
Article
in En
| MEDLINE
| ID: mdl-38590800
ABSTRACT
Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1+ tumor-associated macrophages (TAM) both in the tumor and the tumor draining lymph nodes, thereby blunting the efficacy of therapeutic immunization. Only the combination of the DC vaccine with anti-PD-L1 immune checkpoint inhibition, but not the use of antibodies targeting PD-1 alone, was able to set off CD8+ cytotoxic T lymphocyte (CTL)-mediated tumor suppression in mice. In sum, we delineated a PD-L1 checkpoint blockade-based strategy to avoid TAM-induced T cell exhaustion during DC vaccine therapy.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vaccines
/
B7-H1 Antigen
Limits:
Animals
Language:
En
Journal:
Oncoimmunology
Year:
2024
Type:
Article
Affiliation country:
France