Palladium-Catalyzed Iodine Assisted Carbonylation of Indoles with ClCF2CO2Na and Alcohols.
J Org Chem
; 89(8): 5871-5877, 2024 Apr 19.
Article
in En
| MEDLINE
| ID: mdl-38595315
ABSTRACT
A palladium-catalyzed iodine-assisted carbonylation reaction of indoles with readily available ClCF2CO2Na and alcohols has been developed. This protocol provides a practical and efficient approach to highly regioselective indole-3-carboxylates via a preiodination strategy of indoles. Different from classic carbonylation using toxic and difficult-to-handle carbon monoxide, this operationally simple and scalable reaction employed difluorocarbene as the carbonyl surrogate.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2024
Type:
Article