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Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition.
Cárdenas-Rodríguez, Noemi; Ignacio-Mejía, Iván; Correa-Basurto, Jose; Carrasco-Vargas, Humberto; Vargas-Hernández, Marco Antonio; Albores-Méndez, Exal Manuel; Mayen-Quinto, Rodolfo David; De La Paz-Valente, Reynita; Bandala, Cindy.
Affiliation
  • Cárdenas-Rodríguez N; Laboratorio de Neurociencias, Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
  • Ignacio-Mejía I; Laboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, UDEFA, Mexico City 11200, Mexico.
  • Correa-Basurto J; Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
  • Carrasco-Vargas H; Dirección de la Escuela Militar de Graduados de Sanidad, UDEFA, Mexico City 11200, Mexico.
  • Vargas-Hernández MA; Subdirección de Investigación, Escuela Militar de Graduados en Sanidad, UDEFA, Mexico City 11200, Mexico.
  • Albores-Méndez EM; Subdirección de Investigación, Escuela Militar de Graduados en Sanidad, UDEFA, Mexico City 11200, Mexico.
  • Mayen-Quinto RD; Laboratorio de Biología Molecular, Escuela Militar de Graduados en Sanidad, Mexico City 11200, Mexico.
  • De La Paz-Valente R; Laboratorio de Medicina Traslacional Aplicada a Neurociencias, Enfermedades Crónicas y Emergentes, Escuela superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
  • Bandala C; Laboratorio de Medicina Traslacional Aplicada a Neurociencias, Enfermedades Crónicas y Emergentes, Escuela superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Int J Mol Sci ; 25(7)2024 Mar 29.
Article in En | MEDLINE | ID: mdl-38612615
ABSTRACT
The post-COVID condition (PCC) is a pathology stemming from COVID-19, and studying its pathophysiology, diagnosis, and treatment is crucial. Neuroinflammation causes the most common manifestations of this disease including headaches, fatigue, insomnia, depression, anxiety, among others. Currently, there are no specific management proposals; however, given that the inflammatory component involves cytokines and free radicals, these conditions must be treated to reduce the current symptoms and provide neuroprotection to reduce the risk of a long-term neurodegenerative disease. It has been shown that cannabis has compounds with immunomodulatory and antioxidant functions in other pathologies. Therefore, exploring this approach could provide a viable therapeutic option for PCC, which is the purpose of this review. This review involved an exhaustive search in specialized databases including PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, and Clinical Trials. Phytocannabinoids, including cannabidiol (CBD), cannabigerol (CBG), and Delta-9-tetrahydrocannabinol (THC), exhibit significant antioxidative and anti-inflammatory properties and have been shown to be an effective treatment for neuroinflammatory conditions. These compounds could be promising adjuvants for PCC alone or in combination with other antioxidants or therapies. PCC presents significant challenges to neurological health, and neuroinflammation and oxidative stress play central roles in its pathogenesis. Antioxidant therapy and cannabinoid-based approaches represent promising areas of research and treatment for mitigating adverse effects, but further studies are needed.
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Full text: 1 Database: MEDLINE Main subject: Cannabis / Neurodegenerative Diseases / COVID-19 / Hallucinogens Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Type: Article Affiliation country: Mexico

Full text: 1 Database: MEDLINE Main subject: Cannabis / Neurodegenerative Diseases / COVID-19 / Hallucinogens Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Type: Article Affiliation country: Mexico