Sulfate: a neglected (but potentially highly relevant) anion.
Essays Biochem
; 2024 Apr 19.
Article
in En
| MEDLINE
| ID: mdl-38639060
ABSTRACT
Sulfate is an important anion as sulfonation is essential in modulation of several compounds, such as exogens, polysaccharide chains of proteoglycans, cholesterol or cholesterol derivatives and tyrosine residues of several proteins. Sulfonation requires the presence of both the sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and a sulfotransferase. Genetic disorders affecting sulfonation, associated with skeletal abnormalities, impaired neurological development and endocrinopathies, demonstrate the importance of sulfate. Yet sulfate is not measured in clinical practice. This review addresses sulfate metabolism and consequences of sulfonation defects, how to measure sulfate and why we should measure sulfate more often.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Essays Biochem
/
Essays biochem
/
Essays in biochemistry
Year:
2024
Type:
Article
Affiliation country:
Netherlands