Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience.
Mol Cell
; 84(8): 1403-1405, 2024 Apr 18.
Article
in En
| MEDLINE
| ID: mdl-38640893
ABSTRACT
In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover, UV-induced granules contain double-stranded RNA (dsRNA) and trigger a dsRNA response. This work identifies a mechanism for resolving UV-damaged RNA and broadens the types of cytosolic "stress granules" that form.
Full text:
1
Database:
MEDLINE
Main subject:
Stress Granules
Language:
En
Journal:
Mol Cell
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Type:
Article
Affiliation country:
United States