Interictal interleukin-6 and tumor necrosis factor α levels are associated with seizure recurrence in adults with epilepsy.
Epilepsy Behav
; 155: 109786, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38653175
ABSTRACT
BACKGROUND:
Although there are models predicting epilepsy recurrence under different clinical conditions, few studies have examined blood biomarkers. Inflammation plays a crucial role in the occurrence and development of epilepsy. We analyzed inflammatory mediators in a regional hospital-based epilepsy cohort and investigated their relationship with subsequent epilepsy recurrence.METHODS:
Interictal inflammatory mediators were measured in 128 patients diagnosed with epilepsy participating in a prospective study. Inflammatory mediators were compared during the follow-up period between patients who experienced epilepsy recurrence and those who did not. We also assessed the correlation between inflammatory mediators and the time interval until the next recurrence.RESULTS:
Over a median 4-month follow-up period, 41 patients experienced seizure recurrence. Differences in interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels were observed between seizure recurrence and non-recurrence groups. After adjusting for covariates through multivariate Cox regression analysis, the patients in the third IL-6 tertile (>2.31 pg/mL; HR 2.49; 95 % CI 1.00-6.16; P = 0.049) and in the third TNF-α tertile (>0.74 pg/mL; HR 2.80; 95 % CI 1.13-6.92; P = 0.026) had higher risk of seizure recurrence. The time until the next recurrence was negatively correlated with IL-6 level (ρ = - 0.392, P = 0.011).CONCLUSION:
High levels of IL-6 and TNF-α are associated with a higher possibility of seizure recurrence. Future predictive models should also include inflammatory mediators in addition to clinical variables.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Recurrence
/
Seizures
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Epilepsy
Limits:
Adult
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Epilepsy Behav
Journal subject:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Year:
2024
Type:
Article