Your browser doesn't support javascript.
loading
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress.
Diaz-Diaz, Sara; Garcia-Montaner, Andrea; Vanni, Roberta; Murillo-Torres, Marina; Recacha, Esther; Pulido, Marina R; Romero-Muñoz, Maria; Docobo-Pérez, Fernando; Pascual, Alvaro; Rodriguez-Martinez, Jose Manuel.
Affiliation
  • Diaz-Diaz S; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain. Electronic address: sdiaz6@us.es.
  • Garcia-Montaner A; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.
  • Vanni R; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.
  • Murillo-Torres M; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.
  • Recacha E; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain; Centro de Investigación Biomédica en Red
  • Pulido MR; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecc
  • Romero-Muñoz M; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain.
  • Docobo-Pérez F; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecc
  • Pascual A; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hos
  • Rodriguez-Martinez JM; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, Spain, Sevilla, Spain; Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecc
Drug Resist Updat ; 75: 101087, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38678745
ABSTRACT
In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, with involvement in the generation of clinical resistance. Here we evaluate the impact of heterogeneous expression of the SOS response in clinical isolates of Escherichia coli on response to the fluoroquinolone, ciprofloxacin. In silico analysis of whole genome sequencing data showed remarkable sequence conservation of the SOS response regulators, RecA and LexA. Despite the genetic homogeneity, our results revealed a marked differential heterogeneity in SOS response activation, both at population and single-cell level, among clinical isolates of E. coli in the presence of subinhibitory concentrations of ciprofloxacin. Four main stages of SOS response activation were identified and correlated with cell filamentation. Interestingly, there was a correlation between clinical isolates with higher expression of the SOS response and further progression to resistance. This heterogeneity in response to DNA damage repair (mediated by the SOS response) and induced by antimicrobial agents could be a new factor with implications for bacterial evolution and survival contributing to the generation of antimicrobial resistance.
Subject(s)
Key words

Full text: 1 Database: MEDLINE Main subject: Rec A Recombinases / SOS Response, Genetics / Ciprofloxacin / Microbial Sensitivity Tests / Escherichia coli Proteins / Escherichia coli / Anti-Bacterial Agents Limits: Humans Language: En Journal: Drug Resist Updat Journal subject: ANTINEOPLASICOS Year: 2024 Type: Article

Full text: 1 Database: MEDLINE Main subject: Rec A Recombinases / SOS Response, Genetics / Ciprofloxacin / Microbial Sensitivity Tests / Escherichia coli Proteins / Escherichia coli / Anti-Bacterial Agents Limits: Humans Language: En Journal: Drug Resist Updat Journal subject: ANTINEOPLASICOS Year: 2024 Type: Article