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Gastric emptying in newly diagnosed, treatment-naïve Han Chinese with type 2 diabetes and the impact of 4-week insulin pump therapy.
Sun, Yixuan; Luo, Yong; Xiang, Chunjie; Xie, Cong; Huang, Weikun; Sun, Zilin; Jones, Karen L; Horowitz, Michael; Rayner, Christopher K; Ma, Jianhua; Wu, Tongzhi.
Affiliation
  • Sun Y; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Luo Y; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Xiang C; Institute of Diabetes, Southeast University, Nanjing, China.
  • Xie C; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Huang W; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Sun Z; Institute of Diabetes, Southeast University, Nanjing, China.
  • Jones KL; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Horowitz M; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Rayner CK; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
  • Ma J; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  • Wu T; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
Diabetes Obes Metab ; 26(8): 3078-3087, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38698647
ABSTRACT

AIM:

To evaluate gastric emptying (GE) and the glycaemic response to a 75-g oral glucose load in newly diagnosed, treatment-naïve Han Chinese with type 2 diabetes (T2D) before insulin pump therapy, after 4 weeks of insulin pump therapy, and 12-15 months after insulin pump therapy. MATERIALS AND

METHODS:

Twenty participants with T2D (baseline glycated haemoglobin [± SD] 10.7% [± 1.2%] 93 [± 10] mmol/mol) ingested a 75-g glucose drink containing 150 mg 13C-acetate, to determine the gastric half-emptying time, and underwent assessment of plasma glucose and serum insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over 180 min before and after 4 weeks of insulin pump therapy (discontinued for 48 h before re-assessment). Data were compared to those in 19 healthy participants matched for sex and age. After 12-15 months, GE was re-measured in 14 of the T2D participants.

RESULTS:

At baseline, participants with T2D exhibited substantially augmented fasting and post-glucose glycaemia, diminished insulin secretion, and more rapid GE (p < 0.05 each), but comparable GLP-1, compared to healthy participants. Following insulin pump therapy, insulin secretion increased, GLP-1 secretion was attenuated, fasting and post-glucose glycaemia were lower, and GE was slowed (p < 0.05 each). The slowing of GE in T2D participants was sustained over 12-15 months of follow-up.

CONCLUSIONS:

In newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short-term insulin pump therapy. The effect on GE is maintained for at least 12 months.
Subject(s)
Key words

Full text: 1 Database: MEDLINE Main subject: Blood Glucose / Insulin Infusion Systems / Diabetes Mellitus, Type 2 / Gastric Emptying / Hypoglycemic Agents / Insulin Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2024 Type: Article Affiliation country: Australia

Full text: 1 Database: MEDLINE Main subject: Blood Glucose / Insulin Infusion Systems / Diabetes Mellitus, Type 2 / Gastric Emptying / Hypoglycemic Agents / Insulin Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2024 Type: Article Affiliation country: Australia