Immune response of BALB/c mice infected with two strains of Corynebacterium pseudotuberculosis.
Microb Pathog
; 192: 106671, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38729381
ABSTRACT
This work evaluated aspects of the immune response of BALB/c mice infected with Corynebacterium pseudotuberculosis (T1 and C57). The fifteen BALB/c mice were euthanized after 70 days of infection and morphologically evaluated, also analyzing the innate and adaptive immune responses. The C57 strain induced more pronounced morphological changes than the T1 strain. There was an increase in CD4+ and CD8+ T cells identified during infection with the C57 strain. Cytokines of the inflammatory profile IL-1α and IL-6 and regulatory IL-13 and IL-10 presented significant differences. Cytokines IL-2, IL-4, INF-γ, IL-22, IL-21, and IL-27 did not differ significantly between groups. The obtained results contribute to a better understanding of the type of response and the immunological mechanisms involved during infection with different strains of C. pseudotuberculosis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cytokines
/
Corynebacterium pseudotuberculosis
/
CD8-Positive T-Lymphocytes
/
Corynebacterium Infections
/
Mice, Inbred BALB C
Limits:
Animals
Language:
En
Journal:
Microb Pathog
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Brazil