Palladium-Catalyzed Three-Component Cascade Carbonylation Reaction to Construct Benzofuran Derivatives.
J Org Chem
; 89(11): 7741-7746, 2024 Jun 07.
Article
in En
| MEDLINE
| ID: mdl-38741558
ABSTRACT
A novel three-component cyclization carbonylation reaction of iodoarene-tethered propargyl ethers with amine and CO is reported. This palladium-catalyzed cascade reaction undergoes a sequence of oxidative addition, unsaturated bond migration, carbonyl insertion, and nucleophilic attack to deliver the benzofuran skeleton. Both aromatic amines and aliphatic amines could proceed smoothly in this transformation under one atm of CO.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2024
Type:
Article
Affiliation country:
China