Influence of cardiorespiratory fitness on obesity-associated inflammation in women and men: The FATCOR study.
Nutr Metab Cardiovasc Dis
; 34(8): 1942-1949, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38749786
ABSTRACT
BACKGROUND AND AIMS:
Cardiorespiratory fitness has been postulated to lower chronic inflammation in obesity. We assessed sex-specific associations of inflammation with cardiorespiratory fitness in overweight and obese persons. METHODS ANDRESULTS:
Peak oxygen uptake (VO2max) was measured by treadmill in 566 participants (age 48 ± 9 years, 60% women) with body mass index >27.0 kg/m2 in the FAT associated CardiOvasculaR dysfunction (FATCOR) study. Fitness was identified from age- and sex specific reference levels of VO2max. The inflammatory markers C-reactive protein (CRP), serum amyloid A (SAA), kynureninetryptophan ratio (KTR) and pyriodoxic acid ratio (PAr) were measured by mass spectrometry. In the total study population 63% had obesity and 74% were cardiorespiratory unfit. Unfit women had the highest fat percentage and the highest serum levels of CRP and SAA (p < 0.05). In multivariable linear regression analyses in women, higher CRP (ß -0.15, p = 0.001), SAA (ß -0.10, p = 0.03) and PAr (ß -0.09, p = 0.03) were associated with lower VO2max after adjusting for confounders. In multivariable analyses in men, higher PAr (ß -0.14, p = 0.02) was associated with lower VO2max. In multivariable analyses in obese women, higher CRP and PAr remained associated with lower VO2max (p < 0.05), while in obese men there was no significant association. When normalizing VO2max for fat-free mass (VO2maxFFM) higher CRP, SAA and PAr index were associated with lower VO2maxFFM in women, while only higher PAr index was associated with lower VO2maxFFM in men.CONCLUSION:
The association of inflammation with lower cardiorespiratory fitness was more pronounced in women than men, in particular when obesity was present. CLINICAL TRIAL REGISTRATION URL http//www. CLINICALTRIALS gov NCT02805478.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Oxygen Consumption
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Serum Amyloid A Protein
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Biomarkers
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Inflammation Mediators
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Cardiorespiratory Fitness
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Inflammation
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Obesity
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nutr Metab Cardiovasc Dis
Journal subject:
ANGIOLOGIA
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CARDIOLOGIA
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CIENCIAS DA NUTRICAO
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METABOLISMO
Year:
2024
Type:
Article