Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer.
J Agric Food Chem
; 72(21): 12072-12082, 2024 May 29.
Article
in En
| MEDLINE
| ID: mdl-38750669
ABSTRACT
Ganoderma lucidum polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially in T cell-mediated antitumor immunity. In this study, we found that GLP significantly inhibited tumor growth and activated antitumor immunity in colorectal cancer (CRC). In the spleens and tumor tissues, the proportion of cytotoxic CD8+T cells and Th1 helper cells increased, while immunosuppressive Tregs decreased. Additionally, microbiota dysbiosis was alleviated by GLP, and short-chain fatty acid production was increased. Meanwhile, GLP decreased the ratio of kynurenine and tryptophan (Kyn/Trp) in the serum, which contributed to antitumor immunity of T cells. More importantly, the combination of GLP and the immune checkpoint inhibitor anti-PD-1 monoclonal antibody further enhanced the efficacy of anti-PD-1 immunotherapy. Thus, GLP as a prebiotic has the potential to be used in tumor immunotherapy.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Polysaccharides
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Colorectal Neoplasms
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Reishi
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Programmed Cell Death 1 Receptor
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Immunotherapy
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Agric Food Chem
Year:
2024
Type:
Article
Affiliation country:
China