Progress on the function of Mycobacterium T7SS (ESX) secretion system.
Yi Chuan
; 45(12): 1100-1113, 2023 Dec 20.
Article
in En
| MEDLINE
| ID: mdl-38764274
ABSTRACT
Mycobacterium infection can affect the host's immune function by secreting extracellular effector proteins. ESX (or type VII) system plays an important role in the secretion of effector proteins. ESX system is the protein export system in mycobacteria and many actinomycetes. However, how ESX system secretes and underlying mechanism of action remain unclear. In this review, we introduce the components, function, classification of ESX system and the process of substrates transfer to the peripheral space via this system, and discuss the roles of ESX system in antibiotics resistance, persistence, host-phage interaction, new drug targets. We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Mycobacterium
Limits:
Humans
Language:
En
Journal:
Yi Chuan
Journal subject:
GENETICA
Year:
2023
Type:
Article
Affiliation country:
China