Design of a cryptococcus neoformans vaccine by subtractive proteomics combined with immunoinformatics.
Int Immunopharmacol
; 135: 112242, 2024 Jun 30.
Article
in En
| MEDLINE
| ID: mdl-38772296
ABSTRACT
The emergence of Cryptococcus neoformans has posed an undeniable burden to many regions worldwide, with its strains mainly entering the lungs through the respiratory tract and spreading throughout the body. Limitations of drug regimens, such as high costs and limited options, have directed our attention toward the promising field of vaccine development. In this study, the subtractive proteomics approach was employed to select target proteins from databases that can accurately cover serotypes A and D of the Cryptococcus neoformans. Further, two multi-epitope vaccines consisting of T and B cell epitopes were demonstrated that they have good structural stability and could bind with immune receptor to induce desired immune responses in silico. After further evaluation, these vaccines show the potential for large-scale production and applicability to the majority of the population of the world. In summary, these two vaccines have been theoretically proven to combat Cryptococcus neoformans infections, awaiting further experimental validation of their actual protective effects.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Fungal Vaccines
/
Epitopes, B-Lymphocyte
/
Computational Biology
/
Cryptococcosis
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Cryptococcus neoformans
/
Proteomics
Limits:
Animals
/
Humans
Language:
En
Journal:
Int Immunopharmacol
Journal subject:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
Year:
2024
Type:
Article