Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification.
Curr Opin Genet Dev
; 86: 102205, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38776766
ABSTRACT
N6-methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post-transcription levels. Complex interplay between m6A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m6A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m6A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m6A-based epigenetic network.
Full text:
1
Database:
MEDLINE
Main subject:
Histones
/
Adenosine
/
Epigenesis, Genetic
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2024
Type:
Article
Affiliation country:
China