Cytokine and chemokine profiles in the sera of COVID-19 patients with different stages of severity.
Cytokine
; 180: 156653, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38781873
ABSTRACT
INTRODUCTION:
COVID-19 is a viral infection that disturbs the host's immune system and causes an overproduction of cytokines leading to a cytokine storm. The present study aimed to evaluate the serum levels of 27 protein biomarkers to determine their association with COVID-19 disease severity.METHODS:
The serum levels of 89 patients with different degrees of COVID-19 disease severity [asymptomatic (n = 14), moderate (n = 14), severe (n = 30), and critical (n = 31)] and 14 healthy individuals were tested for a panel of 27 cytokines and chemokines using Luminex assay (27 BioPlex Pro Human Cytokine, Bio-rad™).RESULTS:
IL-12, IL-2 and IL-13, as well as IL-17 and GM-CSF were clearly undetectable in asymptomatic patients. IL-8 levels were higher in asymptomatic compared with other groups. Very high levels of IL-6, IL-10 and the chemokines MIP-1α, MCP-1 and IP10 were associated with disease progression, while IL-4 tends to decrease with disease severity.CONCLUSION:
Our study provides more evidence that excessive cytokine synthesis is linked to the disease progression.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Severity of Illness Index
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Cytokines
/
Chemokines
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SARS-CoV-2
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COVID-19
Limits:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Cytokine
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Morocco