Contributions of CSF interleukin-6 elevation to the pathogenesis of myelin oligodendrocyte glycoprotein antibody-associated disease.
Mult Scler
; 30(8): 977-982, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38783607
ABSTRACT
BACKGROUND:
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare neuroinflammatory disorder characterized by acute episodes of central nervous system (CNS) demyelination. Previous studies have reported elevated interleukin (IL)-6 in cerebrospinal fluid (CSF) of MOGAD patients.OBJECTIVE:
We examined if CSF IL-6 level increase is associated with clinical parameters in MOGAD.METHODS:
IL-6 levels were measured using 44 CSF samples during the acute phase and 6 samples during recovery from 34 MOGAD patients, as well as 65 CSF samples from 45 aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4Ab + NMOSD), 107 samples from 76 multiple sclerosis patients, and 45 samples from neurodegenerative disease patients. Associations between IL-6 levels and clinical parameters in MOGAD were also evaluated.RESULTS:
CSF IL-6 levels were significantly comparably elevated during acute-phase in MOGAD and AQP4Ab + NMOSD, but declined following the acute phase. Among MOGAD patients, CSF IL-6 level was significantly correlated with CSF cell count, greater in patients with brain lesions than spinal cord lesions, and higher in CSF than serum, suggesting that excessive IL-6 is produced predominantly in CNS. Neurological recovery was tended to be poorer in MOGAD patients with higher CSF IL-6 level.CONCLUSION:
CSF IL-6 may play important roles in the pathogenesis of MOGAD, especially in CNS inflammation.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Interleukin-6
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Neuromyelitis Optica
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Myelin-Oligodendrocyte Glycoprotein
Limits:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2024
Type:
Article
Affiliation country:
Japan