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Virological Traits of the SARS-CoV-2 BA.2.87.1 Lineage.
Zhang, Lu; Dopfer-Jablonka, Alexandra; Nehlmeier, Inga; Kempf, Amy; Graichen, Luise; Calderón Hampel, Noemí; Cossmann, Anne; Stankov, Metodi V; Morillas Ramos, Gema; Schulz, Sebastian R; Jäck, Hans-Martin; Behrens, Georg M N; Pöhlmann, Stefan; Hoffmann, Markus.
Affiliation
  • Zhang L; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Dopfer-Jablonka A; Faculty of Biology and Psychology, Georg-August-University Göttingen, 37073 Göttingen, Germany.
  • Nehlmeier I; Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.
  • Kempf A; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany.
  • Graichen L; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Calderón Hampel N; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Cossmann A; Faculty of Biology and Psychology, Georg-August-University Göttingen, 37073 Göttingen, Germany.
  • Stankov MV; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
  • Morillas Ramos G; Faculty of Biology and Psychology, Georg-August-University Göttingen, 37073 Göttingen, Germany.
  • Schulz SR; Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.
  • Jäck HM; Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.
  • Behrens GMN; Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.
  • Pöhlmann S; Department of Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany.
  • Hoffmann M; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, 91054 Erlangen, Germany.
Vaccines (Basel) ; 12(5)2024 May 01.
Article in En | MEDLINE | ID: mdl-38793739
ABSTRACT
Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for efficient spread in the population.
Key words

Full text: 1 Database: MEDLINE Language: En Journal: Vaccines (Basel) Year: 2024 Type: Article Affiliation country: Germany

Full text: 1 Database: MEDLINE Language: En Journal: Vaccines (Basel) Year: 2024 Type: Article Affiliation country: Germany