Unique cartilage matrix-associated protein inhibits osteoclast differentiation by alleviating RANKL-induced reactive oxygen species.
Biochem Biophys Res Commun
; 722: 150171, 2024 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-38797151
ABSTRACT
Unique cartilage matrix-associated protein (UCMA) is a γ-carboxyglutamic acid-rich secretory protein primarily expressed in adult cartilage. UCMA promotes osteoblast differentiation and reduces high glucose-induced reactive oxygen species (ROS) production in osteoblasts; however, its role in osteoclasts remains unclear. Since Ucma is not expressed in osteoclasts, treatment with recombinant UCMA protein (rUCMA) was employed to investigate the effect of UCMA on osteoclasts. The rUCMA-treated osteoclasts exhibited significantly reduced osteoclast differentiation, resorption activity, and osteoclast-specific gene expression. Moreover, rUCMA treatment reduced RANKL-induced ROS production and increased the expression of antioxidant genes in osteoclasts. This study demonstrates that UCMA effectively inhibits RANKL-stimulated osteoclast differentiation and oxidative stress.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Osteoclasts
/
Cell Differentiation
/
Reactive Oxygen Species
/
RANK Ligand
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2024
Type:
Article